Xicotencatl II Axayacatl, also known as Xicotencatl the Younger (died 1521), was a prince and war leader of Tizatlan, one of the four confederate altepeme of the Tlaxcallan state, he was considered to be the de facto ruler because of his father’s weakened health at the time of the Spanish Conquest. He is known primarily as the leader of the force that was dispatched from Tlaxcallan to intercept the forces of Hernán Cortés and his Totonac allies as they entered Tlaxcallan territory when going inland from the Veracruz coast.

When fighting the Spaniards he used an ambush strategy; he first engaged the enemy with a small force that feigned a retreat, and then lured the Spaniards back to a better fortified position where the main force waited. The Spaniards retreated when too many of their men were killed or wounded, and they sought a peace treaty with the Tlaxcaltecs. Maxixcatzin, the ruler of Ocotelolco, was in favour of allying with the Spaniards, but Xicotencatl II opposed this idea and continued to fight, nearly wiping out the Spanish force. However, in a crucial moment, the soldiers from Ocotelolco retreated from the battlefield following the orders of Maxixcatzin, and Xicotencatl was forced to accept the proposed peace treaty.

The Spaniards with the Tlaxcaltec forces marched on Tenochtitlan, where they stayed until the Noche Triste, at which time they were forced to flee the city after an Aztec uprising. The remnants of the Spanish forces made it to Tlaxcala where they once again asked for the assistance of the Tlaxcaltec, and where Xicotencatl II once again spoke against helping them. However, Maxixcatzin’s faction was again successful, and the Spaniards stayed in his palace while they regrouped and received reinforcements.

When the final stage of the siege of Tenochtitlan was about to be carried out, Xicotencatl marched on the Aztec capital as the leader of a Tlaxcaltec force attacking from the north and passing by Texcoco. The night before the final march, he was apprehended and accused of treason by Cortés and by the Ocotelolcan warleader Chichimecateuctli, who said that he had tried to flee back to Tlaxcala. He was summarily executed by hanging.